GENERAL PRINCIPLES OF TRANSLATIONAL RESEARCH IN NEUROPSYCHOPHARMACOLOGY CourseCode: 3819Degree: Master's in Translational NeuropsychopharmacologyFaculty of PharmacyYear: Year 1 of Master's in Translational NeuropsychopharmacologySemester: SpringType: RequiredLanguage: SpanishECTS credits: 4.5Lecture: 4.5Laboratory: 0Hours: 112.5Directed: 45Shared: 10Autonomous: 57.5Subject matter: General Principles of Translational Research in NeuropsychopharmacologyModule: Tools and applications in experimental and clinical researchDepartment: Course instructors are responsible for the course content descriptions in English.DescriptionBasic aspects in translational research on psychiatry and neurology. Validity of animal models. Identification of key therapeutic targets. Clinical trials (I, II, and III). Evaluation of human biological subjects and translational research. Pharmacogenomics. Pharmacogenetics. Biomarkers. Impact of translational research on public health.FacultyNameCoordinatorLectureLaboratoryMANZANARES ROBLES, JORGE■■■GARCÍA GUTIERREZ, MARIA SALUD■■NAVARRETE RUEDA, FRANCISCO■■PEIRO PEIRO, ANA MARIA■■CORNO CAPARROS, ANDRES■■PENA PARDO, MARIA DE LOS ANGELES■■ZAPATER HERNANDEZ, PEDRO■■HORGA DE LA PARTE, JOSÉ FRANCISCO■■Professional interestCompetencies and learning outcomesGeneral competenciesUnderstand the need for translational research as a bridge between the discovery of new therapeutic targets in preclinical research and the development of new drugs and their application in neuropsychopharmacology.Update, consolidate, integrate, and evaluate new knowledge in translational neuropsychopharmacology to improve academic, research, and professional activity using continuous self-learning techniques and critical analysis.Recognize the main characteristics of the most important psychiatric and neurological diseases.Identify and apply existing legislation in the field of translational neuropsychopharmacology to ensure respect for the fundamental rights of patients and animals.Understand the relevance of the results obtained from animal experimentation in advancing therapeutic management of patients with psychiatric and neurological diseases.Possess and understand theoretical-practical and computer knowledge that permits designing studies in the area of translational neuropsychopharmacology.Develop sufficient autonomy to join groups of basic and clinical research in the area of neuropsychopharmacology.Learn how to express the results obtained in multidisciplinary contexts in the area of translational neuropsychopharmacology orally and in writing.Acquire the necessary skills to develop academic, professional, and research activities in the area of translational neuropsychopharmacology.Specific competenciesIdentify and apply legislation related to animal welfare.Apply the ethical and the deontological code related to the use of experimentation animals.Describe the methods and principles that must be applied when handling food in a translational neuropsychopharmacology laboratory.Promote continuous learning as a tool for updating knowledge related to translational neuropsychopharmacology.Understand the general principles of translational research in neuropsychopharmacology.Learn to design and plan clinical trials that permit evaluating the therapeutic use of targets identified in animal modeling studies on neurological and psychiatric diseases.Learn to design and plan research projects in the area of translational neuropsychopharmacology.Acquire the necessary capabilities to disseminate the knowledge obtained in clinical studies and trials with animal models in the form of scientific articles with an international impact.Learn to design and conduct animal modeling research by studying videotapes of psychopharmacological practices.Learn to interpret the results obtained by carrying out animal evaluation models of active drugs in the central nervous system by studying videotapes of psychopharmacological practices.Objectives (Learning outcomes)Know how to explain the basic ideas of translational research in neuropsychopharmacology.Know and explain the fundamental aspects of animal modeling in neuropsychopharmacology.Know and explain the diferent clinical assays.Know and explain the fundamental aspects of Pharmacogenetics and Pharmacogenomics in Neuropsychopharmacology.Know and explain the concept, types and significance of biomarkers in translational neuropsychopharmacology.ContentsLecture topicsTeaching unitsBasic concepts of translational research in psychiatry and neurology.Relevance of animal models in translational neuropsychopharmacology.Clinical trials.Pharmacogenetics and Pharmacogenomics.Biomarker identification in human and animal samples.Course contentsBasic bibliographyJames E. Barrett, Joseph T. Coyle, Michael Williams. "Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders". Cambridge Medicine.Robert A. McArthur, Franco Borsini. "Animal and translational models for CNS drug discovery". Elsevier .Complementary bibliographyLinksSoftwareMethodology and gradingGradingTest (55 % of the final score of the subject): 25 multiple choice questions that will be answered on-line the selected day (previously indicated in the schedule). Participation in the discussion forum (45 % of the final score of the subject). The participation in the forum will be evaluated according to the contributions of each student. The forum will remain opened 24 hours. To pass the subject, will be mandatory the participation of the student in the discussion forum and the test scoren has to be equal or higher than 5.0.