Diffuse interstitial lung disease (ILD). Bronchiolitis obliterans. Idiopathic pulmonary fibrosis. Histiocytosis X. Alveolar proteinosis. Lymphangioleiomyomatosis.
- Recognize the structure of the alveolar-interstitial region, indicating the phenotypic and functional characteristics of local immune cells. Identify the basic immunological aspects involved in the pathogenesis of ILD (from inflammatory alveolitis to established fibrosis).
- Describe the pathologic spectrum of ILD. Current classification. Differentiate idiopathic from secondary to known etiologies.
- Based on the understanding of the structural lesions, to deduct the common pathophysiological functional alterations secondary to the EPID, depending on the degree of involvement and evolutionary state.
- Lay the groundwork for the syndromic diagnosis of ILD. To describe the clinical, radiological and functional characteristics of idiopathic forms.
- Synthesize and critique diagnostic methods. Establish a second level of evaluation focused to etiologic diagnosis and determine disease activity.
- Plan the diagnostic approach to ILD justifying the use of complementary explorations from low to high aggressiveness: chest HRCT, bronchoscopy, surgical lung biopsy.
- To know the natural history of the various EPID; learn the basis of treatments and establish a strategy for monitoring the patient.
- Define the concept of bronchiolitis obliterans.
- List and systematize its various etiologies.
- Outline the pathogenetic mechanisms that influence their origin and development.
- Describe the symptoms and signs, specifying features that can help to its clinic individualization and pathologic correlation.
- To characterize the profiles of the functional disorders that it causes.
- List and describe its sequels.
- Indicate situations that justify the use of invasive techniques to ensure their diagnosis.
- Exhibit therapeutic approach and prognosis.
- Define the concept of histiocytosis X. To characterize the histological lesion that identifies it. Describe clinical-Rx picture, evolution and complications.
- Define the concept of Alveolar proteinosis. Outline the etiopathogenic theories and their relation to opportunistic infections. Describe the clinical and radiological picture. Report prognosis and method of treatment.
Define the concept of Lymphangioleiomyomatosis. To characterize the histological lesion that identifies it. Describe clinical-Rx picture, evolution and complications.
Thoracic sarcoidosis. Hemoptysis. Pulmonary hemorrhage.
- Define the concept of Sarcoidosis as multisystem granulomatous disease of unknown etiology.
- List the various organs that may be affected by this process, indicating the relative frequency. Analyze etiopathogenic theories. Learn their epidemiological profile.
- Describe the objectified immunopathological alterations in this disease at alveolar level.
List three anatomo-pathological features of sarcoid granuloma.
- Describe the most common clinical conditions.
- Distinguish the radiological changes at different stages.
- Exhibit the functional and immunological alterations found.
- Describe the methods used for diagnosis, showing their specificity and sensitivity. Elaborate a sequential diagnostic algorithm for the clinico-radiological suspicion. Arguing the role of serum ACE, scintigraphy with galio67, respiratory function tests, bronchoscopy with biopsies and bronchoalveolar lavage. Possible indication and location of biopsies.
- Indicate the prognosis of its various forms.
- Describe therapeutic plan, numbering the situations that its makes indicated.
- Define the concept of hemoptysis.
- Define the concept of massive hemoptysis.
- Indicate the differential characteristics between hemoptysis and hematemesis.
- List the processes that most often cause hemoptysis.
- List and describe the findings from adequate diagnostic methods to demonstrate the source of subglottic bleeding.
- Describe treatment regimens, making a critical assessment of the usual measures employed.
- Report the conditions required for the indication of surgical therapy.
- Sort diffuse pulmonary hemorrhage syndromes.
- Describe clinical presentation, diagnostic and therapeutic findings of idiopathic hemosiderosis and Goodpasture syndrome.
- Describe Wegener's granulomatosis. Recognize its characteristic clinical features and distinguish them from those produced by other pulmonary granulomatosis.