UMH - MEDICINAL CHEMISTRY I

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MEDICINAL CHEMISTRY I

Course

Code: 1692

Degree: Bachelor's in Pharmacy

Faculty of Pharmacy

Year: Year 3 of Bachelor's in Pharmacy

Semester: Fall

Type: Required

Language: Spanish

ECTS credits: 6

Lecture: 3

Laboratory: 3

Hours: 150

Directed: 60

Shared: 10

Autonomous: 80

Subject matter: Pharmaceutical Chemistry

Module: Chemistry

Department: Pharmacology, Pediatrics and Organic Chemistry

Area: ORGANIC CHEMISTRY

Course instructors are responsible for the course content descriptions in English.

Description

Basic concepts of pharmaceutical chemistry. Metabolism. Structure-activity relationships. Optimization of drugs. Modification of molecular models to improve physicochemical and pharmacokinetic properties.

Faculty

Name	Coordinator	Lecture	Laboratory
FERNANDEZ LAZARO, FERNANDO	■	■	■
GUTIERREZ VILCHEZ, ANA MARIA			■
ZINK LORRE, NATHALIE			■
MOLINA ALCAIDE, DESIRE			■

Professional interest

Situation in the curriculum:
Química Farmacéutica I is a compulsory semester course (first half) taught in the Degree in Pharmacy, in the third year, with a workload of 6 ECTS credits.
Contents addressed in the course are important to the subjects Química Farmacéutica II (compulsory third year), Farmacología y Farmacoterapia I (compulsory third year), Farmacología y Farmacoterapia II (compulsory third year) and Farmacología y Farmacoterapia III (compulsory fourth year).

Background needed:
Students should have previously passed Técnicas de Laboratorio, Química Orgánica I and Química Orgánica II.

Interest for future career:
The design, synthesis and drug development is a career for Graduates in Pharmacy, which can be addressed in any of its phases in single-discipline or multidisciplinary teams with the participation of organic chemists. The knowledge gained in this course will help the pharmacist to do his/her work independently, or actively working as part of a team that share a common language.

Competencies and learning outcomes

General competencies

Hypothesize, assess information, and promote viable solutions to cases and professional situations.
Ability to analyze, evaluate, and assess individual and group situations, identify problems, interpret data, and formulate solutions to individual and/or group problems.
Assess information critically and apply the scientific method to improve the profession.
Ability to update, consolidate, and integrate new knowledge to improve the profession using continuous self-learning techniques and critical analysis.

Specific competencies

Identify, design, obtain, analyze, control, and produce drugs and medicines, as well as other products and raw materials with a health interest for human and/or veterinary use.
Design, prepare, supply, and dispense medicines and other health products of interest.

Professional competencies

Identify, design, obtain, analyze, and produce active ingredients, drugs, and other products and materials of health interest.
Perform standard laboratory procedures, including the use of scientific equipment for synthesis and analysis, including proper instrumentation.
Know and understand the characteristic properties of elements and their compounds, as well as their application in the pharmaceutical field.
Know and understand the nature and behavior of functional groups in organic molecules.
Know the origin, nature, design, acquisition, analysis, and control of medications and health products.
Know and apply the main techniques of structural research including spectroscopy.

Objectives (Learning outcomes)

01Knowing the basic terminology of the Medicinal Chemistry
02Knowing the basic types of receptors
03Being familiar with the metabolic reactions that drugs can undergo and being able to make simple predictions
04Understanding the qualitative and the quantitative structure-activity relationships
05Being familiar with the descriptors of the properties of organic compounds and being able to make critical comments, based upon them, about the most appropriate substituents in a drug
06Understanding and being able to use the semi-quantitative methods for the design of series
07Knowing the different strategies for obtaining prodrugs from different functional groups and their application in the resolution of pharmacokinetic problems
08Knowing about the different strategies for obtaining hard and soft drugs
09Using the Organic Chemistry knowledge to the synthesis of drugs
010Performing simple synthesis of drugs in the laboratory

Teaching units

Association between objectives and units

Objective/Unit	U1	U2	U3
01
02
03
04
05
06
07
08
09
010

Basic bibliography

Complementary bibliography

Methodology and grading

Methodology

Lecture: Pass on knowledge and activate cognitive processes in students, encouraging their participation.
Solving exercises and problems: Exercise, test, and apply previous knowledge through routine repetition.

Grading

Attendance at Laboratory Practicals is obligatory. Depending upon individual diligence in the laboratory (behaviour, interest shown, laboratory record book), students will receive a grading as pass/failed, on completion of the programme of practicals. Only those students with a pass grade in the laboratory programme can successfully complete the course. Students without a pass grade in the laboratory practicals have to undertake a special written examination about the laboratory practical classes, which will take place at the same time as the final examination within the official calendar in February/September/December.

The examination papers will be marked out of a total of 10 points, of which 8 correspond to theory questions and problem-solving, and 2 for questions relating to laboratory practical classes.

The course will be successfully completed after a total mark equal to or higher than 5 is achieved and a pass grade has been given in the laboratory programme. Students who do not have a pass grade in the laboratory practicals, also have to undertake a special written examination about the laboratory practical classes; if they fail, they suspend the subject with the note that they have obtained in this examination.

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