The specific mechanisms established by microorganisms during the course of evolution to colonize the tissues of higher organisms and, collaterally, the damage caused during infectious diseases.
Concepts of infection, disease, pathogenicity and virulence. Commensal microbiota, opportunistic pathogens. Evolution of Koch's postulates. Extent of the infection and virulence.
Mechanisms of adhesion and colonization of the surfaces of the skin and mucous membranes, cell invasion and dissemination.
Evade the immune system: Capsules, mimicry, antigenic variation, resistance to phagocytosis and intracellular killing.
Mechanisms for secretion of toxins. Endotoxins, exotoxins and superantigens.
Genetic factors of virulence and pathogenicity islands. Genetic methods in molecular diagnostics: strategies for detection of virulence factors and resistance.