The combat strategy "invented" to mediate and cause activation of natural defense against infection: immunoprophylaxis.Attenuated vaccines, inactivated, subunit, recombinant peptide, anti-idiotype DNA vaccines. Genetically modified dendritic cells as vaccine antigens vehiclesDesign of nanoparticles and microparticles for vaccine vehicle. DNA plasmids adjuvants. Micro-GMO as vehicles.The seasonal antigenic variability. Antibacterial vaccines. Prevention of zoonoses. Vaccines against parasites. Other vaccines: antitumor, antiallergic, etc..Vaccine efficacy and safety. Side effects. Animal model validation, clinical trials phases I, II, III, and IV. Quality controls.