This group is comprised of Ana Gomis (Staff Scientist at the Spanish National Research Council (CSIC)), Laura Almaraz (UMH Associate Professor of Physiology), Clara Faura (UMH Professor), Carlos Belmonte (UMH Professor & UMH Professor Emeritus and Member of the Royal Academy of Medicine of the Valencian Community), Félix Viana (Scientific Researcher at the CSIC), Alejandro González Álvarez (PhD, UMH Research Personnel), Jorge Fernández Trillo (PhD Researcher, CSIC), Ana Miralles (UMH Research Personnel), Mireille Tora (UMH Research Personnel), and Eva Quintero (UMH Staff & Laboratory Technician).
This group also collaborates with the Moléculas Bioactivas Research Group.
Sensory terminals in our peripheral tissues are subjected to continuous exposure by external physical and chemical stimuli, which must be transformed into a code of electrical signals for their subsequent analysis by the central nervous system. This process is called sensory transduction, whose details are largely ignored, above all in the case of stimuli that give rise to the sensation of pain.
This interdisciplinary group is comprised of diverse investigators with a common objective: to understand the fundamental mechanisms of sensory transduction underlying the sensation of pain, as well as examine the effects of drugs and chemical mediators that can interfere with the activation of pain transduction mechanisms, striving to identify new therapeutic targets.
We want to learn the roles played by different ion channels, which are expressed in afferent nerve terminals, in the process of sensory transduction, as well as determine the distinct response thresholds and mechanisms that intervene in their adaptation and sensitization to distinct and potentially harmful signals. We also investigate the functional changes that sensory neurons undergo during the development of and after injuries to their target tissues. This research objective is to establish the mechanisms that underlie neuropathic-type pain, which is frequently accompanied by hyperexcitability of the damaged afferents.
This group's base is the Institute of Neurosciences at the Miguel Hernández University of Elche, a mixed center with the Spanish National Research Council.